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Methocarbamol is a white powder, sparingly soluble in water as well as chloroform, dissolvable in alcoholic beverages (just with heating) and also propylene glycol, as well as insoluble in benzene as well as n‑hexane.





The system of action of methocarbamol in human beings has not been experienceded, however may be because of basic CNS depression. It has no direct action on the contractile system of striated muscle mass, the motor end plate or the nerve fiber.





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In healthy volunteers, the plasma clearance of methocarbamol arrays between 0.20 and 0.80 L/h/kg, the mean plasma elimination half-life varies between 1 and also 2 hrs, and also the plasma healthy protein binding varies between 46 % and also 50 %.





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Methocarbamol is metabolized using dealkylation and also hydroxylation. Conjugation of methocarbamol also is likely. Essentially all methocarbamol metabolites are removed in the pee. Little quantities of unchanged methocarbamol likewise are excreted in the urine.





The mean ( ± SD) removal half-life of methocarbamol in senior healthy volunteers (mean ( ± SD) age, 69(± 4)years)was somewhat extended as compared to a younger ( mean(± SD)age, 53.3(± 8.8)years), healthy population (1.5 ( ± 0.4) hours versus 1.1 ( ± 0.27) hour, respectively). The portion of bound methocarbamol was a little decreased in the elderly versus more youthful volunteers (41 to 43 % versus 46 to 50 %, specifically).

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